- Encoded in regions HLA-D which has 3 sub regions HLA-DR ,HLA-DP &HLA-DQ
- Antigen binding cleft is alpha1 and beta 1 domains
- Bind to exogenous antigens
- Recognised only by CD4+T cells
- Distribution restricted to Antigen presenting cells namely macrophages,dendritic cells and beta cells
- Expression by other cells especially endothelial cells and fibroblasts can be induced by Interferon gamma
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