These are red cell inclusion bodies made of insoluble denatured proteins.They are seen when the red cells are stained with methyl violet stain and supravital staining.
Sample to be taken: Blood mixed with EDTA.
Significance:They are are seen close to the RBC membrane.they are removed in the spleen and so their presence is frequent in splenectomy.
Causes:
1.Oxidative hemolysis
-chlorates,phenacetin etc
-G6PD deficiency and other enzymopathies
2.Unstable hemoglobins
Sample to be taken: Blood mixed with EDTA.
Significance:They are are seen close to the RBC membrane.they are removed in the spleen and so their presence is frequent in splenectomy.
Causes:
1.Oxidative hemolysis
-chlorates,phenacetin etc
-G6PD deficiency and other enzymopathies
2.Unstable hemoglobins
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